SRP4647

ガレクチン-7 ヒト

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• 別名: Gal-7, Galectin7, HKL-14, PI7, p53誘導遺伝子1タンパク質, ガレクチン7
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥98% (HPLC); ≥98% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: ~15.4 kDa
• 包装: pkg of 50 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: endotoxin, tested
• NCBIアクセッション番号: P47929
• UniProtアクセッション番号: P47929
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... LGALS7(3963)

詳細

詳細

LGALS7 (galectin-7) is from the galectin family of β-galactoside-binding proteins. It is mainly present in the stratified epithelia, hair follicles and thymic Hassall′s corpuscles. The protein localizes in the nucleus and cytoplasm, and exists as a homodimer. Recombinant Human Galectin-7 is a 15.4kDa protein consisting of 136 amino acid residues

生物化学的／生理学的作用

LGALS7 (galectin-7) helps in maintaining skin homeostasis, particularly after skin injury. It is also involved in keratinocyte proliferation and differentiation via JNK1 (c-Jun N-terminal kinase)-miR-203-p63 pathway. LGALS7 is a biomarker for skin condition and skin barrier disruption. In HeLa cells, it induces apoptosis most likely via JNK signaling. LGALS7 is downregulated in SV40-transformed cells and squamous cell carcinoma cells. Change in its activity/expression is associated with the progression of various epithelia-associated cancers. LGALS7 also helps in postmenstrual endometrial re-epithelialization.

物理的形状

凍結乾燥品(ろ過滅菌済み、添加物不含)。

再構成

バイアルは、開封前に遠心してください。凍結融解の繰り返しは避けてください。

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.