F8512

Anti-Fibrinogen antibody produced in goat

whole antiserum

• 別名: Anti-Fib2
• MDL番号: MFCD00162408
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: goat
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: whole antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 含みます: 15 mM sodium azide
• 交差性: human
• テクニック: indirect ELISA: 1:10,000; quantitative precipitin assay: 2.0 mg/mL
• UniProtアクセッション番号: P02671
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FGA(2243) , FGB(2244) , FGG(2266)

詳細

詳細

Fibrinogen is a thrombin-coagulable soluble plasma 340 kDa glycoprotein, composed of paired sets of three subunits i.e. α, β, γ. It plays a crucial role in protecting the vascular network against the loss of blood after tissue injury. Among three subunits, β and γ subunits contain one N-glycosylation site, which is occupied by a biantennary N-glycan. It contains three pairs of disulfide-bonded chains called α, β and γ which further folded into four structural domains: the D, E, connector, and the COOH-terminal region of the Aα chain.

The fibrinogen gene cluster consists of fibrinogen α, β and γ chains. It is localized on human chromosome locus 4q31.3−4q32.1.

特異性

抗血清は、ヒト血漿とフィブリノ-ゲンの免疫電気泳動より、フィブリノ-ゲンに対して免疫特異的であることを判定しています。

免疫原

ヒトフィブリノ-ゲン

アプリケーション

Anti-Fibrinogen antibody is suitable for immunostaining in fibrin deposition analysis of mouse livers and capturing antibodies in the sandwich ELISA. It is also suitable for indirect ELISA at a dilution of 1:10,000 and quantitative precipitin assay at 2.0mg/mL concentration.

Anti-Fibrinogen antibody produced in goat has been used in:

• western blotting detection in human colon adenocarcinoma cell line
• detecting fibrinogen in plasma
• immunoassay of human platelet free plasma (PFP)

生物化学的／生理学的作用

Plasmin attacks the Aα chain COOH domain to produce the heterogeneous fragment X. Multiple round of degradation ended with terminal digestion products−fragments D and E which represent the major globular domains in fibrinogen. Mutations in this gene lead to several disorders, including hypofibrinogenemia and afibrinogenemia.

調製ノート

treated to remove lipoproteins

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable