F2177

Follistatin 288 from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

• 別名: FS-288
• MDL番号: MFCD03456879
• UNSPSCコード: 51111800
• NACRES: NA.32

特性

• 由来生物: mouse
• 品質水準: 100
• リコンビナント: expressed in baculovirus infected Sf21 cells
• アッセイ: >95% (SDS-PAGE)
• フォーム: lyophilized powder
• 有効性: 0.04-0.4 mg per mL
• 分子量: calculated mol wt ~31 kDa
• 包装: pkg of 25 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: endotoxin, tested
• UniProtアクセッション番号: P47931
• 保管温度: −20°C
• 遺伝子情報: mouse ... Fst(14313)

詳細

詳細

FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.

生物化学的／生理学的作用

FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.

High affinity activin-binding protein that can act as an activin antagonist.

物理的形状

組み換えマウスフォリスタチン288は、約25 μgのタンパク質凍結乾燥品(0.2 μmフィルターろ過済み30%アセトニトリル、0.1% TFA溶液(1.25 mgのBSA含有))です。

アナリシスノート

生物活性は、アクチビンによって誘導されるK562細胞の赤血球分化に対する中和能で測定しています。

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Danger
• 危険有害性情報: H315,H318
• 注意書き: P280 - P305 + P351 + P338 + P310
• 危険有害性の分類: Eye Dam. 1 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable