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主要文書

EHU023131

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human LAMC2

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About This Item

UNSPSCコード:

41105324

NACRES:

NA.51

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Sigma-Aldrich

EHU026821

MISSION^® esiRNA

Sigma-Aldrich

G5251

DL-グリセルアルデヒド 3-リン酸溶液

Sigma-Aldrich

900923

Ritonavir-d₆

SIRNA

MISSION^® siRNA Product Offerings

Sigma-Aldrich

39705

D-Glyceraldehyde 3-phosphate 溶液

Sigma-Aldrich

G2267

グリセルアルデヒド 3-リン酸デヒドロゲナーゼウサギ筋肉由来

Sigma-Aldrich

SAB5700741

Anti-CD36 antibody produced in rabbit

$抗GRP78/BiP (ET-21) ウサギ宿主抗体 IgG fraction of antiserum, buffered aqueous solution$

Sigma-Aldrich

G9043

抗GRP78/BiP (ET-21) ウサギ宿主抗体

NIST2242A

Relative Intensity Correction Standard for Raman Spectroscopy: 532 nm Excitation

Roche

RPOLSP6-RO

SP6 RNA ポリメラーゼ

詳細

製品種目

MISSION^®

フォーム

lyophilized powder

esiRNA cDNA標的配列

TTCAGCTGTCCAGCTTGCTATAATCAAGTGAAGATTCAGATGGATCAGTTTATGCAGCAGCTTCAGAGAATGGAGGCCCTGATTTCAAAGGCTCAGGGTGGTGATGGAGTAGTACCTGATACAGAGCTGGAAGGCAGGATGCAGCAGGCTGAGCAGGCCCTTCAGGACATTCTGAGAGATGCCCAGATTTCAGAAGGTGCTAGCAGATCCCTTGGTCTCCAGTTGGCCAAGGTGAGGAGCCAAGAGAACAGCTACCAGAGCCGCCTGGATGACCTCAAGATGACTGTGGAAAGAGTTCGGGCTCTGGGAAGTCAGTACCAGAACCGAGTTCGGGATACTCACAGGCTCATCACTCAGATGCAGCTGAGCCTGGCAGAAAGTGAAGCTTCCTTGGGAAACACTAACATTCCTGCCTCAGACCACTACGTGGGGCCAAATGGCTTTAAAAGTCTGGCTCAGGAGGCCACAAGATTAGCAGAAAGCCACGTTGAGTCA

Ensembl |ヒトアクセッション番号

ENSG00000058085

NCBIアクセッション番号

NM_005562

輸送温度

ambient

保管温度

−20°C

遺伝子情報

human ... LAMC2(3918) , LAMC2(3918)

詳細

MISSION^® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

法的情報

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

10 - Combustible liquids

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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Elevated serum LAMC2 is associated with lymph node metastasis and predicts poor prognosis in penile squamous cell carcinoma.

Qiang-Hua Zhou et al.

Cancer management and research, 10, 2983-2995 (2018-09-15)

Molecular biomarkers, especially serologic factors, have been widely applied in cancer diagnosis and patient follow-up. However, there are few valuable prognostic factors in penile squamous cell carcinoma (PSCC). Here, the authors investigated whether laminin gamma 2 (LAMC2) expression, especially serum

LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein.

Yan Liang et al.

Cell death and differentiation, 25(11), 1980-1995 (2018-03-08)

Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Long noncoding RNAs (lncRNAs) are thought to play a critical role in cancer development. Recently, lncRNA CASC9 was shown to be dysregulated in many cancer types, but the

Silencing of LAMC2 Reverses Epithelial-Mesenchymal Transition and Inhibits Angiogenesis in Cholangiocarcinoma via Inactivation of the Epidermal Growth Factor Receptor Signaling Pathway.

Yao-Fei Pei et al.

The American journal of pathology, 189(8), 1637-1653 (2019-07-28)

Cholangiocarcinoma (CCA) is a malignant cancer that is associated with high mortality rates. The relationship between laminin γ 2 chain gene (LAMC2) and epidermal growth factor receptor (EGFR) has been previously documented in gastric cancer and oral squamous cell carcinoma.

Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin.

Manoj Garg et al.

Scientific reports, 7(1), 9749-9749 (2017-08-31)

Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies having no effective treatment. Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human cancers. In this study, we examined

3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry.

D O Velez et al.

Nature communications, 8(1), 1651-1651 (2017-11-23)

The topographical organization of collagen within the tumor microenvironment has been implicated in modulating cancer cell migration and independently predicts progression to metastasis. Here, we show that collagen matrices with small pores and short fibers, but not Matrigel, trigger a

主要文書

MISSION^® esiRNA