E7402

エラスチン ヒト皮膚由来

insoluble powder

• CAS番号: 9007-58-3
• EC Number: 232-701-4
• MDL番号: MFCD03456696
• UNSPSCコード: 12352202
• NACRES: NA.61

特性

• 由来生物: human skin
• 品質水準: 100
• 形状: powder
• テクニック: ligand binding assay: suitable
• UniProtアクセッション番号: P15502
• 保管温度: 2-8°C
• InChI: 1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1
• InChI Key: DPUYCSDGMSDKKV-MKBYFEBXSA-N
• 遺伝子情報: human ... ELN(2006)

詳細

詳細

Elastin is an extracellular matrix protein encoded by the gene ELN, which is mapped to human chromosome 7q11.23. Elastin is a major protein component of elastic fibres and is synthesized from the precursor protein called tropoelastin. Elastin is present in all the vertebrates except for the primitive fish. Elastin is majorly composed of glycine, proline and other hydrophobic residues.

アプリケーション

Elastin from human skin has been used as a substrate for the enzyme reaction with age-related NADH oxidase (arNOX) using fluorescein-conjugated tyramine.

Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.

生物化学的／生理学的作用

Elastin is essential for resilience of arteries, and other elastic tissues like lungs and skin. Polymorphism in ELN gene causes intracranial aneurysm. Loss of function or haploinsufficiency of ELN gene leads to supravalvular aortic stenosis (SVAS). Frameshift mutations in ELN gene is implicated in congenital cutis laxa resulting in skin laxity and affect pulmonary and cardiovascular system.

調製ノート

Starcherらに記述されているように、ペプチド結合開裂を最小限に抑えるため、穏和な抽出条件下で調整されます。

アナリシスノート

最終純度は、ブタエラスタ-ゼによる分解後のアミノ酸分析と残存不溶残基割合(%)により求められます。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)