C8195

補体C4 ヒト血清由来

≥300,000 C4H50 units/mg protein

• CAS番号: 80295-48-3
• MDL番号: MFCD00130838
• UNSPSCコード: 12352202
• NACRES: NA.61

特性

• 由来生物: human serum
• 品質水準: 200
• 形状: solution
• 比活性: ≥300,000 C4H50 units/mg protein
• テクニック: activity assay: suitable
• UniProtアクセッション番号: P0C0L4
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... C4A(720)

詳細

詳細

Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein.

アプリケーション

Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples.

生物化学的／生理学的作用

Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway.

Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.

補体C4の欠乏は全身性エリテマトーデス(SLE)や、その他の自己免疫疾患の誘発と相関性を示すことが顕著に認められています。

物理的形状

PBS(pH 7.2)溶液。

その他情報

より詳細な情報につきましては、www.sigma-aldrich.com/enzymeexplorerの補体経路をご覧ください。

免責事項

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable