204886

Complement C4, Human

Complement C4, Human, CAS 80295-48-3,is a native glycoprotein composed of three non-identical subunits of 93, 75, and 32 kDa linked by disulfide bonds.

• 別名: Complement C4, Human
• CAS番号: 80295-48-3
• MDL番号: MFCD00130838
• UNSPSCコード: 12352202
• NACRES: NA.25

特性

• 品質水準: 100
• アッセイ: ≥90% (SDS-PAGE)
• フォーム: liquid
• 比活性: >3X10⁵ C4H50 units/mg protein
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles
• 輸送温度: dry ice
• 保管温度: −70°C

詳細

詳細

Native, human C4 complement component. Glycoprotein composed of three non-identical subunits of M.W. 93,000 (α), 75,000 (β), and 32,000 (γ) linked by disulfide bonds. Present in normal human serum at 400 µg/ml. On activation of complement via the classical pathway, the C1s subcomponent of the C1 complex is converted to an active serine protease that cleaves the C4 α-chain at peptide bond 77, resulting in the production of C4a (M.W. 8740) and C4b fragments (M.W. 193,000). The released C4a peptide is one of the three complement-derived anaphylatoxins. The nascent C4b fragment can form a covalent ester bond with target surfaces. This covalent attachment of C4b to target acceptors is required for continuation of activation via classical pathway.

生物化学的／生理学的作用

≥60% of the C4 activity present in freshly drawn normal human serum on a mg to mg basis

包装

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

その他情報

Janatova, J. 1983. Ann. N.Y. Acad. Sci. 421, 218.
Hammer, C.H., et al. 1981. J. Biol. Chem. 256, 3995.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable