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Merck

C7805

Sigma-Aldrich

モノクロナール抗コラーゲン, III型 マウス宿主抗体

clone FH-7A, ascites fluid

別名:

Anti-Collagen III antibody

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About This Item

MDL番号:
UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

mouse

品質水準

結合体

unconjugated

抗体製品の状態

ascites fluid

抗体製品タイプ

primary antibodies

クローン

FH-7A, monoclonal

分子量

antigen 70 kDa

含みます

15 mM sodium azide

化学種の反応性

human, rat

テクニック

dot blot: suitable
immunohistochemistry (frozen sections): 1-4,000 using frozen sections of human skin
indirect ELISA: suitable
western blot: suitable using a denatured-reduced preparation

アイソタイプ

IgG1

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... COL3A1(1281)
rat ... Col3a1(84032)

詳細

Collagen is a fibrous protein present in the extracellular framework of all vertebrates. Collagen type III is a 300 kD molecule that belongs to fibrillar collagens family found mainly in skin, blood vessels, liver, placenta, tongue and thymus. This collagen is directly or indirectly involved in several genetic diseases like Ehlers-Danlos type IV disease. Monoclonal anti-collagen type III antibody can be used to determine the interstitial collagen I and III content in total protein homogenates. It is also used to study the immunolocalization of collagen type III in normal and neoplastic tissue. Mouse monoclonal anti-collagen type III antibody reacts specifically with native and denatured collagen type III but not with collagen types I, II, IV, V, VI, and X.
Collagen is a fibrous protein present in the extracellular framework of all vertebrates. Collagen type III is a 300 kD molecule that belongs to fibrillar collagens family found mainly in skin, blood vessels, liver, placenta, tongue and thymus. This collagen is directly or indirectly involved in several genetic diseases like Ehlers-Danlos type IV disease. Mouse monoclonal anti-collagen type III antibody reacts specifically with native and denatured collagen type III but not with collagen types I, II, IV, V, VI, and X. This product has also shown reactivity for rat and human collagen type III.
Monoclonal Anti-Collagen Type III (mouse IgG1 isotype) is derived from the FH-7A hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human collagen type III.

特異性

Monoclonal Anti-Collagen Type III reacts specifically with native and denatured collagen type III. It does not recognize collagen types I, II, IV, V, VI, and X.

免疫原

ヒトIII型コラ-ゲン。

アプリケーション

Monoclonal Anti-Collagen, Type III antibody produced in mouse has also been used in enzyme linked immunosorbent assay (ELISA) and immunohistochemistry.
Monoclonal anti-collagen type III antibody has been used in immunofluorescence and western blot.

生物化学的/生理学的作用

This collagen is directly or indirectly involved in several genetic diseases like Ehlers-Danlos type IV disease. Monoclonal anti-collagen type III antibody can be used to determine the interstitial collagen I and III content in total protein homogenates.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

C7805-100UL:
C7805-BULK:
C7805-0.2ML:
C7805-VAR:
C7805-.2ML:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons
Butler DL, et al.
Nature Protocols, 5(5), 849-849 (2010)
Corinne N Riggin et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37(9), 2035-2042 (2019-05-02)
Overuse-induced tendinopathy is highly prevalent in the general population. Percutaneous fenestration, or dry needling, techniques have been increasing in popularity, but despite their current use, there are no controlled laboratory studies to provide fundamental support for this practice. The objective
Ana I Gonçalves et al.
PloS one, 8(12), e83734-e83734 (2014-01-05)
Current treatments for tendon injuries often fail to fully restore joint biomechanics leading to the recurrence of symptoms, and thus resulting in a significant health problem with a relevant social impact worldwide. Cell-based approaches involving the use of stem cells
Advanced glycation end products as a source of artifacts in immunoenzymatic methods
Kuzan A, et al.
Glycoconjugate Journal, 35(1), 95-103 (2018)
Fluorescently labeled collagen binding proteins allow specific visualization of collagen in tissues and live cell culture
Krahn KN, et al.
Analytical Biochemistry, 350(2), 177-185 (2006)

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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