おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
lyophilized powder
化学種の反応性
mouse, rat, pig, human
テクニック
western blot (chemiluminescent): 1:200 using rat brain membranes
UniProtアクセッション番号
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CACNA2D1(781)
mouse ... Cacna2d1(12293)
rat ... Cacna2d1(25399)
詳細
CACNA2D1 (calcium channel, voltage-dependent, α2/δ subunit 1) is a member of a family of GPI-anchored voltage-gated calcium channels (VGCCs)-associated subunits called α2δ. VGCC are composed of three types of subunits- pore-forming α1 and auxiliary β and α2δ subunits.
免疫原
ウサギカルシウムチャネルα2/δ−1前駆体のアミノ酸27-41に相当する合成ペプチド。この配列はウサギ, ブタ, ヒトで同一です。ラット, マウスと高い相同性があります(14/15アミノ酸一致)。
アプリケーション
Anti-Calcium Channel (α2/δ-1 Subunit) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生物化学的／生理学的作用
CACNA2D1 (calcium channel, voltage-dependent, α2/δsubunit 1) is a type of α2δs, which are involved in the synaptic neurotransmitter release as they are concentrated at the synapses. They have a chaperone-like activity in non-neuronal cells. This protein acts as a target for gabapentin, which is a neuropathic analgesic. Mutations in this gene, in humans result in short QT syndrome (SQTS).
ターゲットの説明
L-type of Voltage-gated Ca2+ Channel.
物理的形状
凍結乾燥品 (PBS, pH 7.4, 1%BSA, 0.05%アジ化ナトリウム含有)。
調製ノート
0.05 mLのバイアルは、50 μLの脱イオン水で復元してください。0.2 mLのバイアルは、0.2 mLの脱イオン水で復元してください。復元後の抗体濃度は約0.8 mg/mLです。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our 製品選択ツール.
保管分類コード
11 - Combustible Solids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Yuki Domon et al.
The Journal of pharmacology and experimental therapeutics, 365(3), 573-582 (2018-03-23)
Mirogabalin ([(1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid), a novel ligand for the α2δ subunit of voltage-gated calcium channels, is being developed to treat pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. In the present study, we investigated the in vitro binding characteristics and
Macroglia-derived thrombospondin 2 regulates alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure
Wang S, et al.
Testing, 12(9), e0185388-e0185388 (2017)
K Brickley et al.
FEBS letters, 364(2), 129-133 (1995-05-08)
Polyclonal antibodies were raised against peptides corresponding to residues 1-15, 469-483 and 933-951 of the rabbit skeletal muscle L-type calcium channel alpha 2/delta primary translation product, for use as topological probes. Immunocytochemical comparison of the abilities of the antibodies to
Transcription Factor Sp1 Regulates the Expression of Calcium Channel $\alpha$2$\delta$-1 Subunit in Neuropathic Pain
Gomez k, et al.
Neuroscience, 12(9), e0185388-e0185388 (2019)
The alpha 2 delta-1-NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory
Zhou J, et al.
The Journal of Biological Chemistry, 293(50), 19354-19364 (2018)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）