C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me)フルオロメチルケトン

≥90% (TLC), powder

• 別名: Z-IETD-FMK
• 実験式（ヒル表記法）: C₃₀H₄₃FN₄O₁₁
• CAS番号: 220760-26-9
• 分子量: 654.68
• MDL番号: MFCD01861686
• UNSPSCコード: 12352209
• PubChem Substance ID: 329774744
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥90% (TLC)
• 形状: powder
• 溶解性: methanol: 10 mg/mL; DMSO: 20 mM, clear, colorless to light yellow
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
• InChI: 1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
• InChI Key: CTXDBLYOEUERAT-VUVYEONESA-N

詳細

Amino Acid Sequence

Z-Ile-Glu-OMe-Thr-Asp-OMe-FMK

アプリケーション

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

• to study the activity of caspase-8 in porcine kidney cells
• to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
• to study its effects on retinal ganglion and astroglia in rat eyes

生物化学的／生理学的作用

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.

特徴および利点

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)