235420

Caspase-3 Inhibitor I

The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

• 別名: Caspase-3 Inhibitor I, CPP32/Apopain Inhibitor, Ac-DEVD-CHO
• 実験式（ヒル表記法）: C₂₀H₃₀N₄O₁₁
• CAS番号: 169332-60-9
• 分子量: 502.47
• MDL番号: MFCD00671412
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥90% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: 5 mg/mL; water: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1
• InChI Key: UMBVAPCONCILTL-MRHIQRDNSA-N

詳細

詳細

A specific and reversible inhibitor of CPP32/Apopain/Yama (IC₅₀ = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.

A very potent, specific, and reversible inhibitor of caspase-3 (IC₅₀ = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Capase-3, capase-6, capase-7, capase-8, capase-10

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 200 pM against caspase-3

包装

Yes

警告

Toxicity: Standard Handling (A)

シーケンス

Ac-Asp-Glu-Val-Asp-CHO

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature376, 37.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable