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Key Documents

データシートなど

627610

Sigma-Aldrich

Caspase Inhibitor I

Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.

別名:

Caspase Inhibitor I, Z-VAD (OMe)-FMK

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About This Item

実験式（ヒル表記法）:
C22H30FN3O7
CAS番号:
187389-52-2
分子量:
467.49
UNSPSCコード:
12352200

品質水準

100

形状

solid

メーカー／製品名

Calbiochem®

保管条件

OK to freeze
desiccated

色

white

溶解性

DMSO: 50 mM

輸送温度

ambient

保管温度

−20°C

InChI

1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

InChI Key

MIFGOLAMNLSLGH-QOKNQOGYSA-N

詳細

A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. Shown to enhance the freeze-thaw survival of human embryonic stem cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required.
A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.

生物化学的／生理学的作用

Cell permeable: yes
Primary Target
Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

シーケンス

Z-Val-Ala-Asp(OMe)-CH₂F*

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

アナリシスノート

Single spot by TLC

その他情報

Heng, B.C., et al. 2007. Biosci. Rep.27, 257.
Martin, U., et al. 2007. Apoptosis12, 525.
Misaghi, S., et al. 2004. Chem. Biol.11, 1677.
Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
An, S. and Know, K.A. 1996. FEBS Lett.386, 115.
Cain, K., et al. 1996. Biochem J.314, 27.
Mirzoeva, O.K., et al. 1996. FEBS Lett.396, 266.
Pronk, G.J., et al. 1996. Science 271, 808.
Slee, E.A., et al. 1996. Biochem. J.315, 21.
Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
Zhu, H., et al. 1995. FEBS Lett.374, 303.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書（COA）

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Slide 1 of 5

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Caspase Inhibitor Set I The Caspase Inhibitor Set I controls the biological activity of Caspase-1. This collection of small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

235429

Caspase Inhibitor Set I

Caspase-1 Inhibitor VI Caspase-1 Inhibitor VI, Z-YVAD-FMK, is a potent, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5.

Sigma-Aldrich

218746

Caspase-1 Inhibitor VI

ネクロスタチン-1 ≥98% (HPLC)

Sigma-Aldrich

N9037

ネクロスタチン-1

Q-VD-OPh 水和物 ≥95% (HPLC)

Sigma-Aldrich

SML0063

Q-VD-OPh 水和物

Caspase-1 Inhibitor I, Cell-Permeable The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

400011

Caspase-1 Inhibitor I, Cell-Permeable

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