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由来生物
synthetic (organic)
品質水準
無菌性
non-sterile
フォーム
powder
溶解性
DMSO: soluble 14 mg/mL at ≤60 °C
H2O: insoluble
輸送温度
ambient
保管温度
room temp
SMILES記法
[H][C@@]12CC[C@@]3([H])[C@]4([H])CCC[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@H](O)C2
InChI
1S/C19H32O/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18/h13-17,20H,3-12H2,1-2H3/t13-,14-,15-,16-,17-,18-,19-/m0/s1
InChI Key
DJTOLSNIKJIDFF-LOVVWNRFSA-N
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アプリケーション
5α-Androstan-3β-ol has been used as a cortisone analog to test its effect on the voltage-dependent potassium channel (Kv) current.
生物化学的／生理学的作用
mCAR(構成型アンドロスタンレセプタ-)の逆アゴニストであり、テストステロンの代謝産物です。
危険有害性情報
注意書き
危険有害性の分類
Aquatic Chronic 4
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
A2480-50MG:
A2480-VAR:
A2480-BULK:
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A Kassam et al.
The Journal of biological chemistry, 275(6), 4345-4350 (2000-02-08)
The genes encoding the first two enzymes of the peroxisomal beta-oxidation pathway, acyl-CoA oxidase (AOx) and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (HD), contain upstream cis-acting regulatory regions termed peroxisome proliferator response elements (PPRE). Transcription of these genes is mediated through the binding
I Tzameli et al.
Molecular and cellular biology, 20(9), 2951-2958 (2000-04-11)
A wide range of xenobiotic compounds are metabolized by cytochrome P450 (CYP) enzymes, and the genes that encode these enzymes are often induced in the presence of such compounds. Here, we show that the nuclear receptor CAR can recognize response
Isabelle Dussault et al.
Molecular and cellular biology, 22(15), 5270-5280 (2002-07-09)
Unlike classical nuclear receptors that require ligand for transcriptional activity, the constitutive androstane receptor (CAR) is active in the absence of ligand. To determine the molecular contacts that underlie this constitutive activity, we created a three-dimensional model of CAR and
Jorge Luiz Vieira Dos Anjos et al.
International journal of pharmaceutics, 345(1-2), 81-87 (2007-06-30)
The interaction of a potent percutaneous penetration enhancer, 1,8-cineole, with the stratum corneum (SC) and DPPC membranes was investigated by electron paramagnetic resonance spectroscopy (EPR) of spin-labeled analogs of stearic acid (5-DSA) and androstanol (ASL). The EPR spectra of lipid
Andrea Toell et al.
Journal of cellular biochemistry, 85(1), 72-82 (2002-03-14)
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily that regulate target gene transcription in a ligand-dependent manner. CAR and PXR have a rather broad, overlapping set of ligands that range from natural
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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