SML1527

Abiraterone acetate

≥98% (HPLC)

• 別名: CB 7598, 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate
• 実験式（ヒル表記法）: C₂₆H₃₃NO₂
• CAS番号: 154229-18-2
• 分子量: 391.55
• MDL番号: MFCD00934213
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825944
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CN=C5
• InChI: 1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1
• InChI Key: UVIQSJCZCSLXRZ-UBUQANBQSA-N
• 遺伝子情報: human ... CYP17A1(1586)

詳細

アプリケーション

Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.

生物化学的／生理学的作用

Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer. Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.

安全性情報

• ピクトグラム: GHS08,GHS09
• シグナルワード: Danger
• 危険有害性情報: H360F,H373,H410
• 注意書き: P202 - P260 - P273 - P280 - P308 + P313 - P391
• 危険有害性の分類: Aquatic Chronic 1 - Repr. 1B - STOT RE 2
• ターゲットの組織: Endocrine system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable