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About This Item
実験式（ヒル表記法）:
C8H15N3O4
CAS番号:
分子量:
217.22
MDL番号:
UNSPSCコード:
12352209
PubChem Substance ID:
NACRES:
NA.26
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製品名
Ala-Gln, ≥98% (HPLC)
品質水準
アッセイ
≥98% (HPLC)
フォーム
powder
色
white to off-white
SMILES記法
NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O
InChI
1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1
InChI Key
HJCMDXDYPOUFDY-WHFBIAKZSA-N
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関連するカテゴリー
アプリケーション
L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture as alternative delivery forms of stabilized L-glutamine. The primary advantage of using L-alanylglutamine in place of L-glutamine is that it reduces the level of ammonia generated during cell culture.
生物化学的／生理学的作用
Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro.
保管分類コード
11 - Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
A0550-BULK:
A0550-5G:
A0550-1G:
A0550-VAR:
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試験成績書（COA）
Lot/Batch Number
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G Biolo et al.
Nutrition (Burbank, Los Angeles County, Calif.), 13(9 Suppl), 52S-57S (1997-09-18)
The metabolic response to trauma and sepsis involves an increased loss of body proteins. Specific sites of changes of protein and amino acid metabolism have been identified. In skeletal muscle, the rate of proteolysis is accelerated greatly. The rate of
A Christie et al.
Biotechnology and bioengineering, 64(3), 298-309 (1999-07-09)
Although glutamine is a major carbon source for mammalian cells in culture, its chemical decomposition or cellular metabolism leads to an undesirable excess of ammonia. This limits the shelf-life of glutamine-supplemented media and may reduce the cell yield under certain
John D Biggers et al.
Reproductive biomedicine online, 9(1), 59-69 (2004-07-20)
A comparison of the effects of replacing L -glutamine with either glycyl-L-glutamine or alanyl-L-glutamine in a KSOM-type medium on the development of mouse preimplantation embryos in vitro has been made. Alanyl-L-glutamine has no significant effect on the rates of blastocyst
J Mühling et al.
Amino acids, 22(1), 39-53 (2002-05-25)
The objective of this study was to determine the effects of arginine, L-alanyl-L-glutamine (Ala-Gln) or taurine on polymorphonuclear leucocyte (PMN) free amino acid profiles, superoxide anion (O2-) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase activity (MPO). Arginine led to
M Holecek et al.
Amino acids, 22(1), 95-108 (2002-05-25)
The mechanism by which glutamine produces a favorable effect in the treatment of sepsis, injury, burns and abdominal irradiation is not completely understood. The main aim of this study was to evaluate the effect of alanyl-glutamine (AlaGln) administration on the
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