74155

ノナクチン

from Streptomyces sp., ≥97.0% (TLC)

• 別名: アンモニウムイオノフォア
• 実験式（ヒル表記法）: C₄₀H₆₄O₁₂
• CAS番号: 6833-84-7
• 分子量: 736.93
• Beilstein: 76434
• EC Number: 229-911-3
• UNSPSCコード: 51102829
• PubChem Substance ID: 24886652
• NACRES: NA.85

特性

• 由来生物: Streptomyces sp.
• 品質水準: 200
• アッセイ: ≥97.0% (TLC)
• フォーム: powder
• 色: white to faint yellow
• 抗生物質活性スペクトル: Gram-positive bacteria
• 作用機序: DNA synthesis | interferes; cell membrane | interferes; enzyme | inhibits
• 保管温度: 2-8°C
• SMILES記法: C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1
• InChI: 1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
• InChI Key: RMIXHJPMNBXMBU-QIIXEHPYSA-N

詳細

詳細

Chemical structure: macrolide

May contain the homologues monactin and dinactin

アプリケーション

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, as an uncoupler of oxidative phosphorylation, and to inhibit surface expression of certain heat shock proteins (HSP60) .

生物化学的／生理学的作用

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation .

包装

5 mg

その他情報

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.Moisturesensitive. Keep in a dry place.

Natural macrotetrolide

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)