30290

シチジン5'-ジホスホコリン ナトリウム塩 水和物

≥99.0% (HPLC)

• 別名: CDP-コリン-Na
• 実験式（ヒル表記法）: C₁₄H₂₅N₄NaO₁₁P₂ · xH₂O
• CAS番号: 33818-15-4
• 分子量: 510.31 (anhydrous basis)
• Beilstein: 4110040
• MDL番号: MFCD00150508
• UNSPSCコード: 41106305
• PubChem Substance ID: 57648419
• NACRES: NA.51

特性

• 由来生物: synthetic
• アッセイ: ≥99.0% (HPLC)
• 形状: powder
• 不純物: ≤8% water
• 保管温度: 2-8°C
• SMILES記法: [Na+].C[N+](C)(C)CCOP([O-])(=O)OP([O-])(=O)OCC1OC([C@H](O)[C@@H]1O)N2C=CC(N)=NC2=O
• InChI: 1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9?,11-,12-,13?;/m1./s1
• InChI Key: YWAFNFGRBBBSPD-MBWJOHGMSA-M

詳細

アプリケーション

Cytidine 5′-diphosphocholine (CDP-choline) is generated by choline-phosphate cytidylyltransferase EC 2.7.7.15 in support of the synthesis of phosphatidylcholine. CDP-choline is being used in studies of its affects on neurorecovery.

Cytidine 5′-diphosphocholine sodium salt hydrate has been used as a component of the mixture during the ribonucleotide reductase (RNR) assay in mouse primary pancreatic acinar cells.

生物化学的／生理学的作用

Cytidine 5′-diphosphocholine (CDP-choline) is an endogenous compound that plays an important role in the synthesis of phospholipids in the cell membrane. It acts as a choline donor for the biosynthesis of acetylcholine and phosphatidylcholine, a neuronal membrane phospholipid. CDP-choline enhances brain metabolism and influences the levels of various neurotransmitters including dopamine, epinephrine, and acetylcholine. It has been studied as a neuroprotectant after cerebral ischemia. CDP-choline is observed to exhibit therapeutic effects against cognitive impairment arising from multiple causes, cerebral vascular diseases, after-head trauma, and Alzheimer′s disease.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)