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由来生物
mouse
品質水準
100
500
結合体
unconjugated
抗体製品の状態
culture supernatant
抗体製品タイプ
primary antibodies
クローン
MRQ-33, monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
形状
buffered aqueous solution
化学種の反応性
human
包装
vial of 0.1 mL concentrate (276M-94)
vial of 0.5 mL concentrate (276M-95)
bottle of 1.0 mL predilute (276M-97)
vial of 1.0 mL concentrate (276M-96)
bottle of 7.0 mL predilute (276M-98)
メーカー／製品名
Cell Marque™
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
アイソタイプ
IgG1
コントロール
kidney
輸送温度
wet ice
保管温度
2-8°C
視覚化
membranous
遺伝子情報
human ... CDH16(1014)
詳細
Kidney-specific cadherin (Ksp-cadherin) is a novel, kidney-specific member of the cadherin family of cell adhesion molecules. Within the kidney, Ksp-cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Different cadherins, including E-cadherin, cadherin-6, and N-cadherin, have been investigated in renal cell cancers, demonstrating possible correlations of tumor dedifferentiation and the presence of lymph node metastasis with loss of cadherins. Mazal et al. investigated the utility of using Ksp-cadherin to distinguish chromophobe renal cell carcinoma from oncocytoma. He found a membranous pattern of staining in 96% of 30 chromophobe carcinomas, and in only 6% of 31 oncocytomas leading them to conclude that this is a useful antibody in differentiating these two lesions. Shen et al., on the other hand, found Ksp-cadherin positivity in 100% of 13 chromophobe RCCs, and 95% of 20 oncocytomas.
Associated products: CK7, RCC
Associated products: CK7, RCC
品質
 IVD |  IVD |  IVD |  RUO |
関連事項
Ksp-cadherin Positive Control Slides, Product No. 276S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
調製ノート
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
その他情報
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法的情報
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Steven S Shen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 18(7), 933-940 (2005-02-08)
Renal cell neoplasms are presumably derived from different cell types of the nephron. Clear cell and papillary renal cell carcinoma (RCC) are thought to be of proximal tubular origin, whereas oncocytoma and chromophobe RCC are derived from intercalated cells of
Peter R Mazal et al.
Human pathology, 36(1), 22-28 (2005-02-16)
Distinguishing renal oncocytoma from chromophobe and other renal carcinomas is essential, considering their differing biological potentials. Although renal oncocytoma is considered a benign tumor, chromophobe renal cell carcinoma has potentially malignant biological behavior. The numerous reported studies on distinguishing these
C Thedieck et al.
British journal of cancer, 92(11), 2010-2017 (2005-05-12)
Cadherins are a large family of cell-cell adhesion molecules acting in a homotypic, homophilic manner that play an important role in the maintenance of tissue integrity. In the human kidney, several members of the cadherin family (including E- and N-cadherin
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