おすすめの製品
由来生物
mouse
品質水準
100
500
結合体
unconjugated
抗体製品の状態
culture supernatant
抗体製品タイプ
primary antibodies
クローン
MRQ-27, monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
形状
buffered aqueous solution
化学種の反応性
human
包装
vial of 0.1 mL concentrate (272M-14)
vial of 0.5 mL concentrate (272M-15)
bottle of 1.0 mL predilute (272M-17)
vial of 1.0 mL concentrate (272M-16)
bottle of 7.0 mL predilute (272M-18)
メーカー／製品名
Cell Marque™
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
コントロール
brain, endothelial cells
輸送温度
wet ice
保管温度
2-8°C
視覚化
nuclear
遺伝子情報
human ... SMARCB1(6598)
詳細
INI-1, also known as SMARCB1, is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex. It is involved in chromatin remodeling and transcriptional regulation and functions as a tumor suppressor. Nuclear INI-1 expression is seen in virtually all normal human tissues and most malignancies but the INI-1 gene is often mutated or deleted in malignant rhabdoid tumors (MRT), including those arising in the central nervous system, leading to a lack of INI-1 expression.
品質
 IVD |  IVD |  IVD |  RUO |
関連事項
INI-1 Positive Control Slides, Product No. 272S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
調製ノート
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
その他情報
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法的情報
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Christine Haberler et al.
The American journal of surgical pathology, 30(11), 1462-1468 (2006-10-26)
Immunohistochemical lack of nuclear INI1 protein expression has been recently described as characteristic finding in atypical teratoid/rhabdoid tumors (AT/RTs), and has been suggested as useful marker to distinguish AT/RTs from other malignant pediatric central nervous system (CNS) tumors. In this
hSNF5/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities.
F Bourdeaut et al.
The Journal of pathology, 211(3), 323-330 (2006-12-08)
Rhabdoid tumours (RTs) are rare but highly aggressive tumours of childhood. Their rarity and their miscellaneous locations make the diagnosis particularly challenging for pathologists. Central nervous system and peripheral RTs have been associated with biallelic inactivation of the hSNF5/INI1/SMARCB1 (hSNF5/INI1)
D J Fowler et al.
Fetal and pediatric pathology, 25(3), 159-168 (2006-10-25)
Primary extrarenal rhabdoid tumors (RT) are now recognized as a specific entity in pediatric oncological pathology practice. We present an unusual case of a small cell myxoid variant of a thoracic RT in an infant and highlight the importance of
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