おすすめの製品
グレード
pharmaceutical primary standard
APIファミリー
brotizolam
メーカー／製品名
EDQM
drug control
psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
アプリケーション
pharmaceutical (small molecule)
フォーマット
neat
保管温度
2-8°C
SMILES記法
[s]1c2c(cc1Br)C(=NCc4[n]2c(nn4)C)c3c(cccc3)Cl
InChI
1S/C15H10BrClN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
InChI Key
UMSGKTJDUHERQW-UHFFFAOYSA-N
詳細
この製品は薬局方標準品です。発行元の薬局方により製造・供給されています。MSDSを含む製品情報などの詳しい情報は、発行元の薬局方のウェブサイトよりご確認ください。
アプリケーション
Brotizolam EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
この製品は発行元の薬局方による供給としてお届けします。現在の単位量については、EDQM reference substance catalogueをご覧ください。
その他情報
Sales restrictions may apply.
最新バージョンのいずれかを選択してください：
Akshay Anand et al.
Behavioural brain research, 182(1), 12-20 (2007-06-15)
Benzodiazepines such as diazepam, lorazepam, are reported to produce anterograde amnesia but these do not affect the retrieval mechanism. Triazodiazepines such as alprazolam, triazolam and brotizolam produce both anterograde and retrograde amnesia. Because benzodiazepine receptor antagonists are known to reverse
Atsushi Takiguchi et al.
Journal of pharmacological sciences, 101(4), 325-328 (2006-08-08)
Triazolam caused no significant increase in the total error at 0.05 and 0.1 mg/kg. However, at 0.2 mg/kg, it caused a significant increase in total error. Almost the same findings were observed with brotizolam and rilmazafone. That is, at 0.2
Naoko Tanaka et al.
Soudni lekarstvi, 56(1), 5-6 (2011-03-19)
A case of drowning involving brotizolam, flunitrazepam and ethanol ingestion was presented. Quantitative toxicological analysis showed that the concentrations of brotizolam, 7-aminoflunitrazepam (a metabolite of flunitrazepam) and ethanol in the femoral blood were 0.025 microg/ml, 0.094 microg/ml and 0.29 mg/ml
Yoshinori Sugimoto et al.
Bioorganic & medicinal chemistry letters, 23(12), 3515-3518 (2013-05-15)
When the drug product of brotizolam (1) is decomposed according to the interview form and patent, hydrolysate (2) is obtained, but its physicochemical data are still missing. To elucidate the structure based on a spectroscopic approach, the above-mentioned degradation product
Yukihiro Ujiie et al.
Therapeutic drug monitoring, 28(3), 299-302 (2006-06-17)
The purpose of the present study was to examine the effects of rifampicin on the single oral dose pharmacokinetics and pharmacodynamics of brotizolam. Thirteen healthy male volunteers received rifampicin 450 mg/day, or matched placebo, for 7 days in a double-blind
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