SMB00932

2-デオキシ-D-グルコース 6-リン酸 ナトリウム塩

≥98% (HPLC)

• 別名: 2-Deoxy-D-glucose 6-phosphate sodium salt
• 実験式（ヒル表記法）: C₆H₁₃O₈P · xNa⁺
• CAS番号: 33068-19-8
• 分子量: 244.14 (free acid basis)
• MDL番号: MFCD00057477
• UNSPSCコード: 12352201
• NACRES: NA.25

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white
• 溶解性: water: 50 mg/mL, clear, colorless
• 保管温度: −20°C
• SMILES記法: [Na].OC(COP(O)(O)=O)C(O)C(O)CC=O
• InChI: 1S/C6H13O8P.Na.H/c7-2-1-4(8)6(10)5(9)3-14-15(11,12)13;;/h2,4-6,8-10H,1,3H2,(H2,11,12,13);;
• InChI Key: NBDKYLFTCAOTAK-UHFFFAOYSA-N

詳細

詳細

2-Deoxy-D-glucose 6-phosphate sodium salt serves as a crucial intermediate in glycogen degradation. Its production in mammalian cells occurs through the action of hexokinase on 2-Deoxy-D-glucose (2-DG).

2-Deoxy-d-glucose (2DG) is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis). In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate (2DG6P) intracellularly. 2DG & 2DG6P serve as good markers for tissue glucose uptake and hexokinase activity. For example, many cancers have elevated glucose uptake and hexokinase levels. 2DG6P undergoes only the first enzymatic reaction in the pentose phosphate pathway to generate 2-DG-6-phosphogluconolactone, which cannot be further metabolized.

アプリケーション

2-Deoxy-D-glucose 6-phosphate sodium salt is a versatile compound that finds application in metabolomics and biochemical research.

特徴および利点

• High-purity compound suitable for a wide variety of research applications

その他情報

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable