PHR1179

クロロチアジド

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 6-クロロ-2H-1,2,4-ベンゾチアジアジン-7-スルホンアミド 1,1-ジオキシド
• 実験式（ヒル表記法）: C₇H₆ClN₃O₄S₂
• CAS番号: 58-94-6
• 分子量: 295.72
• EC Number: 200-404-9
• MDL番号: MFCD00058576
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823191
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 76; traceable to Ph. Eur. C1700000; traceable to USP 1121005
• APIファミリー: chlorothiazide
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
• InChI: 1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
• InChI Key: JBMKAUGHUNFTOL-UHFFFAOYSA-N
• 遺伝子情報: human ... SLC12A3(6559)

詳細

詳細

Chlorothiazide belongs to the class of thiazide diuretic drugs. It is used for the management of postparturient udder edema in cattle. Its mode of action involves the inhibition of chloride reabsorption in the proximal portion of distal tubule.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

Chlorothiazide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

最初のチアジド系利尿薬の1つでした。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA8998 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H317,H334
• 注意書き: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• 危険有害性の分類: Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable