89802

4-(ジメチルアミノ)アゾベンゼン-4′-スルホニルクロリド

for HPLC derivatization, LiChropur^™, 98.0-102.0% (AT)

• 別名: 4-(4-ジメチルアミノフェニルアゾ)ベンゼンスルホニルクロリド, DABS-Cl, ダブシルクロリド
• 化学式: (CH₃)₂NC₆H₄N=NC₆H₄SO₂Cl
• CAS番号: 56512-49-3
• 分子量: 323.80
• Beilstein: 3064095
• EC Number: 260-235-1
• MDL番号: MFCD00007444
• UNSPSCコード: 12352200
• NACRES: NA.22

特性

• グレード: for HPLC derivatization
• 品質水準: 100
• アッセイ: 98.0-102.0% (AT)
• フォーム: crystals
• 品質: LiChropur^™
• テクニック: HPLC: suitable
• mp: 185 °C (dec.) (lit.)
• SMILES記法: CN(C)c1ccc(cc1)\N=N\c2ccc(cc2)S(Cl)(=O)=O
• InChI: 1S/C14H14ClN3O2S/c1-18(2)13-7-3-11(4-8-13)16-17-12-5-9-14(10-6-12)21(15,19)20/h3-10H,1-2H3/b17-16+
• InChI Key: VTVWTPGLLAELLI-WUKNDPDISA-N

詳細

詳細

Amino groups are common to many biological compounds and many amines used in pharmaceuticals. Most of these compounds show weak absorption in direct HPLC analysis with UV-VIS detection. However, strongly absorbing derivatives of amines can be easily detected by HPLC with high sensitivity even when present at low concentrations. Primary and secondary amino groups are usually derivatized as aromatic derivatives by nucleophilic substitution reactions using reagents such as arylsulfonyl chlorides.
4-(Dimethylamino)azobenzene-4′-sulfonyl chloride, a well-known UV-labeling agent, is generally used for the derivatization of N-terminal amino acids, imidazole derivatives, polyamines, etc. prior to their chromatographic determination due to the former′s capacity to covalently bind to the substrates. Its derivatives typically absorb UV radiation between the range of 436-460 nm. This method of derivatization is regarded as superior compared to other methods owing to the simplicity of the procedure, high stability and reproducibility, best resolution of the analytes, etc.

アプリケーション

4-(Dimethylamino)azobenzene-4′-sulfonyl chloride may be used to derivatize biogenic amines, primary amino acids, melamine, and hydroxyproline and proline extracted from various biological samples prior to their determination using high performance liquid chromatography (HPLC) technique to increase their detection sensitivity.

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法的情報

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Danger
• 危険有害性情報: H314
• 注意書き: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Skin Corr. 1B
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable