38370

N,N′-ジイソプロピルカルボジイミド

purum, ≥98.0% (GC)

• 別名: DIC
• 化学式: (CH₃)₂CHN=C=NCH(CH₃)₂
• CAS番号: 693-13-0
• 分子量: 126.20
• Beilstein: 878281
• EC Number: 211-743-7
• MDL番号: MFCD00065689
• UNSPSCコード: 12352001
• PubChem Substance ID: 329755678
• NACRES: NA.22

特性

• グレード: purum
• 品質水準: 200
• アッセイ: ≥98.0% (GC)
• 形状: liquid
• 反応適合性: reaction type: Coupling Reactions
• 屈折率: n20/D 1.433 (lit.)
• bp: 145-148 °C (lit.)
• 密度: 0.815 g/mL at 20 °C (lit.); 0.815 g/mL at 20 °C
• アプリケーション: peptide synthesis
• SMILES記法: CC(C)N=C=NC(C)C
• InChI: 1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
• InChI Key: BDNKZNFMNDZQMI-UHFFFAOYSA-N
• 遺伝子情報: human ... EPHX2(2053) ; mouse ... Ephx2(13850)

詳細

詳細

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

アプリケーション

N,N′-Diisopropylcarbodiimide can be used:

• To synthesize lanthanide (Ln) guanidinate complexes via insertion of carbodiimide into the Ln-N bond of lanthanocene secondary amido complexes.
• To facilitate the cyclization of N-(β-Hydroxy)amides to form 2-oxazolines.
• To synthesize 1-isopropyl-2-alkoxycarbonyl-3-isopropyliminio-aziridine by reacting with alkyl diazoacetates in the presence of transition metal salts.

DIC can be used as:

• A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively.
• A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction.
• A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea.

ペプチド合成の際のジシクロヘキシルカルボジイミドの代替品。

安全性情報

• ピクトグラム: GHS02,GHS05,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H226 - H317 - H318 - H330 - H334
• 注意書き: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 3
• 引火点(°F): 91.4 °F
• 引火点(℃): 33 °C
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter