26454

ステアリン酸マグネシウム

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

• 別名: ステアリン酸 マグネシウム塩
• 化学式: [CH₃(CH₂)₁₆CO₂]₂Mg
• CAS番号: 557-04-0
• 分子量: 591.24
• Beilstein: 3919702
• EC Number: 209-150-3
• MDL番号: MFCD00036391
• UNSPSCコード: 12352106
• PubChem Substance ID: 57648176
• NACRES: NA.22

特性

• グレード: puriss.
• アッセイ: ≥40% stearic acid basis (GC); ≥90% stearic and palmitic acid basis; 4.0-5.0% Mg basis (calc on dry sub.)
• 品質: meets analytical specification of Ph. Eur., BP
• 不純物: acidity or alkalinity, complies; microbiological impurity, in accordance; residual solvents, complies
• 損失: ≤6.0% loss on drying, 105 °C
• mp: 200 °C (lit.)
• 酸価: 195‑210(fatty acid)
• 溶解性: alcohol: insoluble; diethyl ether: insoluble; water: insoluble
• 微量陰イオン: chloride (Cl^-): ≤1000 mg/kg; sulfate (SO₄^2-): ≤5000 mg/kg
• 微量陽イオン: Cd: ≤3 mg/kg; Ni: ≤5 mg/kg; Pb: ≤10 mg/kg
• 適合性: in accordance for fatty acid composition; passes test for identity
• アプリケーション: pharmaceutical (small molecule)
• SMILES記法: CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
• InChI: 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
• InChI Key: HQKMJHAJHXVSDF-UHFFFAOYSA-L

詳細

アプリケーション

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

生物化学的／生理学的作用

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves