AG938

Synuclein, α, recombinant human

• 別名: α-Synuclein protein, Alpha Synuclein
• UNSPSCコード: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

特性

• 由来生物: human
• 品質水準: 100
• アッセイ: >95% (gel scan and mass spectrometry)
• フォーム: solid
• シェルフライフ: 12 mo.
• メーカー／製品名: Chemicon^®
• 溶解性: water: slightly soluble
• 適合性: suitable for molecular biology
• NCBIアクセッション番号: NM_000345.2; NM_007308.1
• UniProtアクセッション番号: P37840
• 遺伝子情報: human ... SNCA(6622)

詳細

詳細

Research area: Neuroscience

α-Synuclein, a member of the synuclein family of proteins that localize to presynaptic terminals under physiological conditions. It is comprised of three primary regions: an amino terminus containing apolipoprotein lipid-binding motifs, which are anticipated to form amphiphilic helices. The central region, known as non-Aβ component (NAC) containing a hydrophobic domain that gives β-sheet potential, and the carboxyl terminus, characterized by a high negative charge and remains unstructured. Under physiological conditions, members of the synuclein family, including α-synuclein, are predominantly neuronal proteins.

アプリケーション

Synuclein, α, recombinant human has been used:

• for preparation of α-synuclein fibrils to access the SAR228810 antibody against the risk of amyloid-related imaging abnormalities (ARIA).
• to study the formation of isoasparate protein damage responsible to trigger familial Parkionsonian phenotypes.
• to study its interaction with iron and copper, in order to understand their role in proteinopathies.

生物化学的／生理学的作用

Synuclein, α is the principal component of Lewy bodies and a pathological hallmark of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The deposition of αS aggregates is a defining characteristic of all these diseases.

物理的形状

Lyophilized from TBS. Resuspend in water at a concentration of 1 mg/mL.

保管および安定性

Maintain lyophilized material at -20ºC for up to 12 months after date of receipt. After reconstitution maintain at -20ºC to -70ºC for up to 2 weeks in undiluted aliquots. Avoid freeze/thaw cycles to avoid aggregation.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable