ABS88

Anti-phospho-mTOR (Thr2164) Antibody

serum, from rabbit

• 別名: Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapam
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• クローン: polyclonal
• application: DB; WB
• 化学種の反応性: human
• テクニック: dot blot: suitable; western blot: suitable
• citations: 1

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: serum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: human
• テクニック: dot blot: suitable; western blot: suitable
• NCBIアクセッション番号: NP_004949
• UniProtアクセッション番号: P42345
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: phosphorylation (pThr2164)
• 遺伝子情報: human ... MTOR(2475)

詳細

詳細

The mammalian target of rapamycin (mTOR), also known as FRAP, RAFT, or RAPT, is a ubiquitously expressed serine/threonine kinase that belongs to the phosphoinositide 3-kinase–related kinase (PIKK) family. mTOR functions as a downstream effector in the PI3K pathway and is activated by the Akt kinase. mTOR responds to signals from growth factors and promotes protein synthesis underlying cell proliferation, by activation of the S6 kinase and inhibition of the 4E-BP protein involved in protein translation. Several studies have suggested that the proliferative functions of mTOR may contribute to the development of cancer.

特異性

This antibody recognizes mTOR phosphorylated at Thr2164.

免疫原

Epitope: Phosphorylated Thr2164

KLH-conjugated linear peptide corresponding to human mTOR phosphorylated at Thr2164.

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
キナーゼ及びホスファターゼ

Anti-mTOR Antibody is an antibody against phospho-mTOR (Thr2164) for use in Dot Blot, Western Blotting.

Western Blot Analysis: A representative lot was used by an independent laboratory in HEK293 cell lysate. (Ekim, B., et al. (2011). MCB. [Epub ahead of print].)

品質

Dot Blot Specificity Analysis: Unmodified and phosphorylated mTOR peptides were probed with Anti-phospho-mTOR (Thr2164) (1:1,000 dilution).

ターゲットの説明

289 kDa calculated

物理的形状

Unpurified

Rabbit polyclonal serum containing 0.05% sodium azide.

保管および安定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

アナリシスノート

Control
Unmodified and phosphorylated mTOR peptides

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1