ABF189

Anti-FcRn/FCGRT Antibody

from rabbit, purified by affinity chromatography

• 別名: IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FcRn/FCGRT
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: mouse (based on 100% sequence homology), rat (based on 100% sequence homology), feline (based on 100% sequence homology), monkey (based on 100% sequence homology), canine (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_001129491
• UniProtアクセッション番号: P55899
• 輸送温度: dry ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FCGRT(2217)

詳細

詳細

IgG receptor FcRn large subunit p51 (UniProt P55899; also known as FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor) is encoded by the FCGRT gene (also known as FCRN) (Gene ID 2217) in human. Transfer of passive immunity from mother to the fetus or newborn involves the transport of IgG across several epithelia. Depending on the species, IgG is transported prenatally across the placenta and yolk sac or is absorbed from colostrum and milk by the small intestine of the suckling newborn. In both cases, apical to basolateral transepithelial transport of IgG is mediated by FcRn. FcRn is a heterodimer of an alpha-chain and beta(2)-microglobulin (beta(2)m) and differs from other IgG Fc receptors in that it is structurally related to MHC class I molecules. The assembly of the FcRn alpha-chain with beta(2)m is important for both cell surface expression and pH-dependent high affinity IgG binding. Proteins endocytosed from serum are degraded in the lysosomes. However, serum albumin (SA) and IgG bind to FcRn at low pH in the endosome after endocytosis, and are transported back to the cellular surface, where they are released into the bloodstream, resulting in an extended serum half-life.

免疫原

Epitope: Alpha-2/-3 domain

Linear peptide corresponding to the Alpha-2/-3 domain of human FcRn/FCGRT.

アプリケーション

Research Category
炎症及び免疫

Research Sub Category
免疫グロブリン及び免疫

This Anti-FcRn/FCGRT Antibody is validated for use in Western Blotting for the detection of FcRn/FCGRT .

Western Blotting Analysis: A representative lot detected FcRn/FCGRT in FO-1 cells expressing Myc-hFcRn (Praetor, A., et al. (2002). J Cell Sci. 115(Pt11):2389-2397).
Western Blotting Analysis: A representative lot detected FcRn/FCGRT in hFcRn transfected MDCK cells (Praetor, A., et al. (1999). J Cell Sci. 112(Pt14):2291-2299).

品質

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FcRn/FCGRT in 10 µg of human liver tissue lysate.

ターゲットの説明

~35/45 kDa observed, with the lower band representing non- and/or less glycosylated form(s).

物理的形状

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable