ABF184

Anti-IL-21 Antibody

from rabbit, purified by affinity chromatography

• 別名: Interleukin-21, IL-21, Za11
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: bovine (based on 100% sequence homology), porcine (based on 100% sequence homology)
• テクニック: flow cytometry: suitable; western blot: suitable
• NCBIアクセッション番号: NP_068575
• UniProtアクセッション番号: Q9HBE4
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... IL21(59067)

詳細

詳細

Interleukin-21 (UniProt Q9HBE4; also known as IL-21, Za11) is encoded by the IL21 (also known as CVID11) gene (Gene ID 59067) in human. IL-21 is a type I four-alpha-helical bundle cytokine primarily produced by CD4+ T cells and NKT cells. The heterodimeric receptor IL-21R is dominantly expressed by B cells and shares the common cytokine receptor gamma chain (γc) with receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Studies indicate that IL-21 potently regulates both adaptive and innate immune responses and possesses widely pleiotropic functions. IL-21 has also been linked to autoimmune disorders, allergies, inflammatory diseases, as well as the pathogenesis of cancer. Human IL-21 is initially translated with an N-terminal 22 aa signal peptide sequence, which is later removed to produce the 133 aa mature IL-21.

特異性

Expected to react with pro- and mature IL-21 of both isoform 1 and isoform 2 (IL-21iso).

免疫原

Epitope: Near C-terminus

KLH-conjugated linear peptide corresponding to human IL-21 sequence near the C-terminus.

アプリケーション

Research Category
炎症及び免疫

Research Sub Category
免疫グロブリン及び免疫

Flow Cytometry Analysis: 3.0 µg of this antibody detected IL-21 in human peripheral blood mononuclear cells.

This rabbit Polyclonal Anti-IL-21 Antibody, Cat. No. ABF184 is validated for use in Western Blotting, Flow Cytometry, for the detection of IL-21.

品質

Evaluated by Western Blotting in human IL-21 transfected HEK293 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected IL-21 in 10 µg of human IL-21 transfected HEK293 cell lysate.

ターゲットの説明

~17 kDa observed. Uncharacterized band(s) may appear in some lysates.

物理的形状

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable