8.05901

Methyl vinyl ketone

(stabilised) for synthesis

• 別名: Methyl vinyl ketone, 1-Buten-3-one, MVK, Vinyl methyl ketone
• CAS番号: 78-94-4
• 分子量: 70.09
• MDL番号: MFCD00008777
• UNSPSCコード: 12352115
• EC Index Number: 201-160-6
• NACRES: NA.22

特性

• 蒸気圧: 100 hPa ( 20 °C)
• 品質水準: 200
• 形状: liquid
• 自己発火温度: 491 °C
• 有効性: 23.1 mg/kg LD₅₀, oral (Rat); 35 mg/kg LD₅₀, skin (Rat)
• expl. lim.: 2.1-15.6 % (v/v)
• bp: 80-81 °C/1013 hPa
• 転移温度: flash point -7 °C
• 密度: 0.85 g/cm³ at 20 °C
• 保管温度: 15-25°C
• InChI: 1S/C4H6O/c1-3-4(2)5/h3H,1H2,2H3
• InChI Key: FUSUHKVFWTUUBE-UHFFFAOYSA-N

詳細

詳細

Methyl vinyl ketone (MVK) is an organic compound that belongs to the class of enones. It is a useful synthetic reagent in organic synthesis for the preparation of various organic compounds. MVK is a 3-oxobutyl synthon, which undergoes a 1,4 conjugate addition (Michael addition) reaction. MVK is susceptible to anionic polymerization, therefore it is typically stored with hydroquinone, which inhibits polymerization.

アプリケーション

Methyl vinyl ketone can be used as a reagent to synthesize:

• Isocoumarins by a Pd-catalyzed regioselective cyclization reaction with o-alkynylbenzoates in the presence of LiCl.      
• Furan and pyrrole derivatives by Rh-catalyzed 1,4-carbonylative addition reaction with arylboronic acids.      
• Poly(p-hydroxystyrene) compounds via radical copolymerization with p-hydroxystyrene derivatives.     
• Aryl-thiocyanatobutan-2-one derivatives by reacting with aryldiazonium salts in the presence of copper(II) catalysts.

アナリシスノート

Assay (GC, area%): ≥ 93.5 % (a/a)
Density (20°C/ 4°C): 0.850 - 0.860
Water (GC, area%): ≤ 5.0 % (a/a)
Identity (IR): passes test

安全性情報

• ピクトグラム: GHS02,GHS05,GHS06,GHS09
• シグナルワード: Danger
• 危険有害性情報: H225 - H300 + H310 + H330 - H314 - H317 - H410
• 注意書き: P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - Skin Sens. 1
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 3
• 引火点(°F): 19.4 °F
• 引火点(℃): -7 °C