654255

TNF-α Antagonist

≥95% (HPLC), lyophilized, TNF-α antagonist, Calbiochem^®

• 別名: TNF-α Antagonist, TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
• 実験式（ヒル表記法）: C₅₈H₇₁N₁₁O₁₅S₂
• 分子量: 1226.38
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: TNF-α Antagonist, The TNF-α Antagonist controls the biological activity of TNF-α.
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 溶解性: water: 1 mg/mL; 5% acetic acid: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 5 µM as TNF-α antagonist

警告

Toxicity: Standard Handling (A)

シーケンス

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)

その他情報

Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

法的情報

Sold under license of U.S. Patent 6,265,535.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable