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由来生物
human
リコンビナント
expressed in E. coli
アッセイ
≥98% (HPLC)
≥98% (SDS-PAGE)
形状
lyophilized
有効性
20-40 ng/mL
分子量
17.2 kDa
包装
pkg of 100 μg
保管条件
(Keep container tightly closed in a dry and well-ventilated place)
テクニック
activity assay: suitable
不純物
endotoxin, tested
色
white to off-white
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... IL1R1(3554)
詳細
Research area: Immunology & cytokines
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.
アプリケーション
Interleukin-1 receptor antagonist (IL-1RA) human has been used:
- to study the role of interleukin (IL)-1β receptor in cell senescence induced by doxorubicin
- to block the IL-1β binding to its receptor
- to understand the role of autocrine interleukin-1β (IL-1β) signaling downstream of cl- in RPS27 modulation
生物化学的／生理学的作用
Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.
物理的形状
凍結乾燥品(20 mM Tris, pH 8.0)。
再構成
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
抗体
製品番号
詳細
価格
関連製品
製品番号
詳細
価格
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP3327-100UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
The role of cytokines in cancer-related fatigue.
Kurzrock R
Cancer, 92, 1684-1688 (2001)
Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases.
Deage V
European Cytokine Network, 9, 663-668 (1998)
Association of IL-1a rs17561 and IL-1 RN rs315952 polymorphisms with Tourette syndrome: a family-based study.
He F
International Journal of Clinical and Experimental Pathology, 8, 4182-4185 (2015)
Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium.
Sousa AR
American Journal of Respiratory and Critical Care Medicine, 154, 1061-1066 (1996)
Hyperresponsive febrile reactions to interleukin (IL) 1alpha and IL-1beta, and altered brain cytokine mRNA and serum cytokine levels, in IL-1beta-deficient mice.
Alheim K
Proceedings of the National Academy of Sciences of the USA, 94, 2681-2686 (1997)
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