574661

Survivin Antagonist, S12

The Survivin Antagonist, S12 controls the biological activity of Survivin.

• 別名: Survivin Antagonist, S12, Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one
• 実験式（ヒル表記法）: C₁₇H₁₂BrNO₅
• CAS番号: 258264-62-9
• 分子量: 390.18
• MDL番号: MFCD00117860
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 50 mg/mL, nearly colorless
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: O=C(CC1(C(C=C(Br)C=C2)=C2NC1=O)O)C3=CC(OCO4)=C4C=C3

詳細

詳細

A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Berezov, A., et al. 2011. Oncogene31, 1938.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable