481412

NF-kB Activation Inhibitor IV

The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 別名: NF-kB Activation Inhibitor IV, (E)-2-Fluoro-4ʹ-methoxystilbene
• 実験式（ヒル表記法）: C₁₅H₁₃FO
• CAS番号: 139141-12-1
• 分子量: 228.26
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: crystalline solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 溶解性: DMSO: 20 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC₅₀ = 150 nM).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
NF-κB Activation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Heynekamp, J.J., et al. 2006. J. Med. Chem.49, 7182.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable