481480

NF-κB SN50

≥97% (HPLC), lyophilized, NF-κB translocation inhibitor, Calbiochem^®

• 別名: NF-κB SN50, Cell-Permeable Inhibitor Peptide
• 実験式（ヒル表記法）: C₁₂₉H₂₃₀N₃₆O₂₉S
• 分子量: 2781.50
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: NF-κB SN50, Cell-Permeable Inhibitor Peptide, NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.
• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: lyophilized
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 溶解性: water: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.

Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 µM.

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
translocation of the NF-κB active complex into the nucleus

Product does not compete with ATP.

警告

Toxicity: Standard Handling (A)

シーケンス

H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

その他情報

Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

法的情報

Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany