572636

SU6656

InSolution, ≥95%, inhibitor of Src-family protein tyrosine kinases

• 別名: InSolution SU6656
• 実験式（ヒル表記法）: C₁₉H₂₁N₃O₃S
• 分子量: 371.45
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 輸送温度: wet ice
• 保管温度: 2-8°C

詳細

詳細

A potent inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ >10 µM) and IGF-1 receptor kinase (IC₅₀ gt;20 µM).

生物化学的／生理学的作用

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target IC₅₀: 280 nM inhibiting Src

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572635) in DMSO.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)