529576

PP2

≥95% (HPLC), liquid, Src protein tyrosine kinase inhibitor, Calbiochem^®

• 別名: InSolution PP2
• 実験式（ヒル表記法）: C₁₅H₁₆ClN₅
• 分子量: 301.77
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: PP2, InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: clear colorless
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

詳細

A potent and selective inhibitor of the src family of tyrosine kinases. Its action is similar to PP1. Selectively inhibits p56^lck (IC₅₀ = 4 nM), p59^fynT (IC₅₀ = 5 nM), and Hck (IC₅₀ = 5 nM) compared to other tyrosine kinases, such as EGF-R (IC₅₀ = 480 nM), JAK2 (IC₅₀ >50 µM) or ZAP-70 (IC₅₀ >100 µM). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC₅₀ = 600 nM).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
p56^lck

Product competes with ATP.

Reversible: yes

Target IC₅₀: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529573) in DMSO.

再構成

Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).

その他情報

Hanke, J.H., et al. 1996. J. Biol. Chem.271, 695.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)