5.31042

ICI 182,780

≥98% (HPLC), powder, GPR30 agonist, Calbiochem^®

• 別名: Estrogen Receptor Antagonist, ICI 182,780, GPR30 Agonist, ICI 182,780, ICI 182780, ICI182780
• 実験式（ヒル表記法）: C₃₂H₄₇F₅O₃S
• CAS番号: 129453-61-8
• 分子量: 606.77
• MDL番号: MFCD00903953
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: Estrogen Receptor Antagonist, ICI 182,780,
• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 100 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
• InChI Key: VWUXBMIQPBEWFH-WCCTWKNTSA-N

詳細

詳細

A cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.



Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable estrogen antagonist. More effective than tamoxifen in reducing estrogen receptors in breast tumor cells.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
ER

Secondary Target
GPR30

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Wakeling, A. E., et al. 1991. Cancer Res.51, 3867.
Dauvois, S., et al. 1993. J. Cell. Sci.106, 1377.
Howell, A., et al. 1995. The Lancet.8941, 29.
Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol.79, 209.

法的情報

Sold with the permission of AstraZeneca UK. Limited for research purposes only.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 危険有害性情報: H413
• 注意書き: P273 - P501
• 危険有害性の分類: Aquatic Chronic 4
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3