528180

Plasminogen, Glu-Type, Human Plasma

• 別名: Glu-type plasminogen, Plasminogen
• UNSPSCコード: 12352202
• NACRES: NA.25

特性

• 形状: liquid
• 品質水準: 100
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles
• その他の活性: Plasmin, none detected
• 輸送温度: wet ice
• 保管温度: −70°C

詳細

詳細

Native Glu-type plasminogen from human plasma. Plasminogen is a single chain glycoprotein found in normal plasma at ~12 mg per deciliter, and is the inactive precursor of the serine protease plasmin.

Native Glu-type plasminogen from human plasma. Plasminogen is a single chain glycoprotein zymogen, which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4 µM. The plasminogen molecule contains 790 amino acids, 24 disulfide bridges, no free sulfhydryls, and 5 regions of internal sequence homology, known as kringles, between Lys⁷⁷ and Arg⁵⁶⁰. These kringle regions are homologous to the kringle domains in t-PA, u-PA, and prothrombin. Native Glu-plasminogen is readily converted to Lys⁷⁷-plasminogen by plasmin hydrolysis of the Lys⁷⁶-Lys⁷⁷ peptide bond. The plasminogen is converted to plasmin by cleavage at Arg⁵⁴⁰-Val⁵⁶¹ by urokinase, streptokinase, or tissue plasminogen activator.

警告

Toxicity: Irritant (B)

物理的形状

In 100 mM NaCl, 50 mM Tris-HCl, pH 7.5.

調製ノート

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

再構成

Following initial thaw, aliquot and freeze (-20°C).

アナリシスノート

Single band by SDS-PAGE

その他情報

Collen, D. 1986. In Blood Coagulation (Zwaal, R.E.A., and Hemker, H.C. eds.) Elsevier, N.Y. p. 243.
Barlow, G.H., et al. 1984. Biochemistry23, 2384.
Wohl, R.C., et al. 1982. Thromb. Res.27, 523.
Castellino, F.J., et al. 1981. Methods Enzymol.80, 365.
Robbins, K.C. 1976. Methods Enzymol.45, 257.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable