5.08159

Salvinorin A

• 別名: Salvinorin A, κ-opioid Receptor Agonist, Salvinorin A, Divinorin A
• 実験式（ヒル表記法）: C₂₃H₂₈O₈
• CAS番号: 83729-01-5
• 分子量: 432.46
• MDL番号: MFCD05664742
• UNSPSCコード: 12352200

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: solid
• 有効性: 4.3 nM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: ethanol: 10 mM; DMSO: 50 mM
• 保管温度: −70°C
• InChI: 1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
• InChI Key: OBSYBRPAKCASQB-AGQYDFLVSA-N

詳細

詳細

A highly potent and selective non-alkaloid positive allosteric modulator of Κ-opioid receptors (K_i = 4.3 nM and 16 nM for native and cloned κ-opioid receptors, respectively). Also acts as a D2DR partial agonist (K_i = 5-10 nM). Used in studies of addition.

生物化学的／生理学的作用

Primary Target
k opioid receptor

警告

Toxicity: Standard Handling (A)

その他情報

Roth, B. et al., 2002. PNAS.99, 11934.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3