5.08015

CTOP

• 別名: CTOP, µ Opioid Receptor Antagonist, CTOP
• 実験式（ヒル表記法）: C₅₀H₆₇N₁₁O₁₁S₂
• CAS番号: 103429-31-8
• 分子量: 1062.26
• MDL番号: MFCD00076708
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• 品質水準: 100
• フォーム: solid
• 有効性: 0.96 nM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: water: soluble
• 保管温度: −20°C
• InChI: 1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
• InChI Key: PZWWYAHWHHNCHO-UHFFFAOYSA-N

詳細

詳細

A potent antagonist highly selective for µ opioid receptor (K_i = 0.96 nM for µ receptor and >10,000 nM for δ receptors). Often used for studying the functional roles of µ opioid receptors in both central and peripheral nervous systems.

生物化学的／生理学的作用

Primary Target
mu opioid

警告

Toxicity: Standard Handling (A)

シーケンス

D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Orn: ornithine; Pen: penicillamine; SS bond: 2-7)

物理的形状

Supplied as trifluoracetate salt

その他情報

Feng, Y., et al. 2012. Curr Drug Targets.13, 230.
Hawkins, N., et al. 1989. J. Pharmacol. Exp. Ther.248, 73.
Gulya, K., et al. 1988. Eur. J. Pharmacol.150, 355.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable