506181

p75^NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5

The p75^NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75^NTR. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 別名: p75^NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, TAT-Pep5, H- YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
• 実験式（ヒル表記法）: C₁₅₀H₂₂₇N₅₇O₃₂S₂
• 分子量: 3404.90
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

The p75^NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.

The p75^NTR inhibitor Pep5 (Cat. No. 506180) fused to the N-terminal, 11-amino acid protein transduction domain sequence from the HIV TAT protein for membrane permeability. Show to inhibit the association of p75^NTR with Rho-GDI in vitro. Reported to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion (DRG) and postnatal cerebellar neurons at a concentration of 100 nM. Reported to be a potential therapeutic agent for the inhibition of regeneration in the central nervous system.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH

disulfide bond (12-26)

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

その他情報

Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci.6, 461.
Schwarze, S.R., et al. 1999. Science285, 1569.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable