5.05880

L-745,870 Trihydrochloride

• 別名: L-745,870 Trihydrochloride, Dopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
• 実験式（ヒル表記法）: C₁₈H₁₉ClN₄ · 3HCl
• CAS番号: 158985-00-3
• 分子量: 436.21
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• 形状: solid
• 有効性: 0.4 nM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: water: soluble
• 保管温度: 2-8°C
• InChI: 1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
• InChI Key: OGJGQVFWEPNYSB-UHFFFAOYSA-N

詳細

詳細

Selective D₄ receptor antagonist with excellent brain penetration. Displays an affinity (K_i) of 0.4 nM for human D₄ receptors with >1000-fold binding selectivity over D₂ and D₃ receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D₄ modulation.

生物化学的／生理学的作用

Primary Target
D₄

Reversible: yes

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Li, H. et al., 2013. J. Neurosci.33, 3135.

Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem.39, 1941.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable