484100

5-Nitro-2-(3-phenylpropylamino)benzoic Acid

Potent Cl⁻ channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method.

• 別名: 5-Nitro-2-(3-phenylpropylamino)benzoic Acid, NPPB, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II, ANO Blocker II, Anoctamin Blocker II
• 実験式（ヒル表記法）: C₁₆H₁₆N₂O₄
• CAS番号: 107254-86-4
• 分子量: 300.31
• MDL番号: MFCD00153851
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: yellow
• 溶解性: DMSO: 5 mg/mL; warm ethanol: soluble
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)
• InChI Key: WBSMIPAMAXNXFS-UHFFFAOYSA-N

詳細

詳細

Potent Cl^– channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC₅₀ = 8 µM).

Potent Cl^- channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC₅₀ = 8 µM).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Cl⁻ channel blocker

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM-100 µM as Cl-channel blocker

警告

Toxicity: Standard Handling (A)

その他情報

Illek, B., et al. 1992. Am. J. Physiol.263, C644.
Kirk, K., et al. 1992. J. Biol. Chem.267, 23475.
Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun.163, 398.
Wangermann, P., et al. 1986. Pflugers Arch.407, S128.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable