475872

MnTMPyP

Cell-permeable superoxide dismutase (SOD) mimetic.

• 別名: MnTMPyP, Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide
• 実験式（ヒル表記法）: C₇₂H₆₅MnN₈O₁₃S₄
• 分子量: 1433.53
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (TLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated; protect from light
• 色: black
• 溶解性: water: 1 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O₂^{– •} (rate constant ~4 x 10⁷ M^-1 s^-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O₂^• oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.

生物化学的／生理学的作用

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

その他情報

Izbicka, E., et al. 1999. Cancer Res.59, 639.
Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable