440206

LY 294002, 4′-NH₂

A cell-permeable LY 294002 4′-amino derivative with enhanced potency against p110α/β/δ/γ.

• 別名: LY 294002, 4′-NH₂, 2-(4-Morpholinyl)-8-(4-aminophenyl)-4H-1-benzopyrone-4-one, PI-828
• 実験式（ヒル表記法）: C₁₉H₁₈N₂O₃
• CAS番号: 942289-87-4
• 分子量: 322.36
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 30 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C19H18N2O3/c20-14-6-4-13(5-7-14)15-2-1-3-16-17(22)12-18(24-19(15)16)21-8-10-23-11-9-21/h1-7,12H,8-11,20H2
• InChI Key: WUKMIBOGGXMBAC-UHFFFAOYSA-N

詳細

詳細

A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC₅₀ in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4′-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Gharbi, S.I., et al., 2007. Biochem. J.404, 15.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable