662009

U0126

InSolution, ≥98%, A potent and specific inhibitor of MEK1 and MEK2

• 別名: InSolution U0126
• 実験式（ヒル表記法）: C₁₈H₁₆N₆S₂ · 0.5C₂H₆O
• CAS番号: 109511-58-2
• 分子量: 403.52
• MDL番号: MFCD09971039
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 輸送温度: ambient
• 保管温度: −70°C
• SMILES記法: S(c2c(cccc2)N)\C(=C(\C(=C(\Sc1c(cccc1)N)/N)\C#N)/C#N)\N
• InChI: 1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
• InChI Key: DVEXZJFMOKTQEZ-JYFOCSDGSA-N

詳細

詳細

A potent and specific inhibitor of MEK1 (IC₅₀ = 72 nM) and MEK2 (IC₅₀ = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.

再構成

Following initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).

その他情報

Duncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett.8, 2839.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)