F4425

フォストリエシン ナトリウム塩 from Streptomyces pulveraceus

≥98% (HPLC)

• 実験式（ヒル表記法）: C₁₉H₂₆NaO₉P
• CAS番号: 87860-39-7
• 分子量: 452.37
• MDL番号: MFCD09971059
• UNSPSCコード: 12352200
• PubChem Substance ID: 24894863
• NACRES: NA.77

特性

• 由来生物: Streptomyces sp. (Streptomyces pulveraceous)
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 溶解性: ethanol: soluble; methanol: soluble; water: soluble
• 保管温度: −20°C
• SMILES記法: [Na+].C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)([O-])=O
• InChI: 1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1/b3-2-,6-4+,8-5-,12-11+;/t15-,16+,17+,19+;/m0./s1
• InChI Key: XBUIKNRVGYFSHL-IAVQPKKASA-M

詳細

アプリケーション

Fostriecin has been used as a protein phosphatases type 2A (PP2A) inhibitor to study its effects on phosphorylated myosin light chain (pMLC) levels in axon initial segments (AIS). It has also been used as a PP2A inhibitor to study its effects on the regulation of protein kinase Akt (pAKT) by dopamine (DA) in larval zebrafish brain.

生物化学的／生理学的作用

Fostriecin is a natural inhibitor of serine/ threonine phosphatases. It is a phosphate monoester produced by fermentation beer of Streptomyces pulveraceus. Fostriecin is a strong inhibitor of protein phosphatases type 2A and 4 (PP2A and PP4) and a weak inhibitor of protein phosphatases type 1 and 5 (PP1 and PP5). It exhibits anti-tumor activity against several tumor cells in vitro and L1210 and P388 leukemias in vivo. The anti-tumor activity of fostriecin is due to its ability to interfere with the reversible phosphorylation of proteins that are involved in the progression of the cell cycle. It also exhibits cytotoxic effects. Fostriecin can inhibit the DNA, RNA and protein synthesis.

特徴および利点

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

包装

アルゴン封入包装。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)