437650

Lipopolysaccharide

from Salmonella typhimurium, , lyophilized, iNOS stimulator, Calbiochem

• 別名: Salmonella LPS, Salmonella endotoxin
• UNSPSCコード: 12352201
• NACRES: NA.77

特性

• product name: Lipopolysaccharide, Salmonella typhimurium, Stimulates the activity of inducible nitric oxide synthase.
• 品質水準: 100
• 形状: lyophilized
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 不純物: ≤2% nucleic acid; ≤2% protein
• 溶解性: water: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

Endotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define revelent pathophysiological parameters of endotoxin shock, a profound life-threatening consequence of bacterial sepsis. More recently, these bacterial products have generated intense interest due to their pluripotential immunostimulatory activity, as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cells activated by lipopolysaccharides produce a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Inducible nitric oxide synthase

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful (C)

再構成

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.

その他情報

Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun.63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun.61, 5044.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 2 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable