435800

Licochalcone-A, Synthetic

An estrogenic flavonoid with anti-tumor and antiparasitic properties.

• 別名: Licochalcone-A, Synthetic, (E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
• 実験式（ヒル表記法）: C₂₁H₂₂O₄
• CAS番号: 58749-22-7
• 分子量: 338.40
• MDL番号: MFCD01417903
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥96% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 10 mg/mL; ethanol: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+
• InChI Key: KAZSKMJFUPEHHW-DHZHZOJOSA-N

詳細

詳細

An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.

An estrogenic flavonoid with anti-tumor and antiparasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation, exhibits anti-tumor activity, and enhances the effect of Paclitaxel (Cat. No. 580555) and Vinblastine (Cat. No. 677175) chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Anti-tumor and antiparasitic properties

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

調製ノート

Further dilute 1:10 with aqueous buffer or medium just prior to use.

再構成

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

その他情報

Rafi, M.M., et al. 2000. Anticancer Res. 20, 2653.
Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.
Haraguchi, H., et al. 1998. Phytochemistry 48, 125.
Park, E.J., et al. 1998. Planta Med. 64, 464.
Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.
Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 + H312 + H332
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable